一、基本信息

刘代喜，女，博士，现任开云在线登录官网助理研究员、硕士研究生导师。主要从事新型抗感染及抗肿瘤活性天然产物的发现及功能研究工作。

邮箱：liudaixi@sdu.edu.cn

二、教育及工作经历

2022.12-至今，开云在线登录官网，助理研究员

2020.7-2022.11，山东大学海洋研究院，博士后

2016.09-2020.7，山东大学海洋研究院，海洋生物学，博士

三、研究方向

 

1）海洋蓝细菌来源的活性次级代谢产物挖掘及其生物合成途径研究；

2）药用动物来源的活性毒素多肽的发现及功能研究。

 

四、代表性论文

1. Liu Daixi^#;Lv Haibo^#; Wang Yafei^#; Chen Jinyu; Li Dexin; Huang Ranran*; Selective RNA processing and stabilization are multi-layer and stoichiometric regulators of gene expression inEscherichia coli, Advanced Science, 2023, 2301459.

2. Liu Daixi;Chen Jinyu; Wang Yafei; Meng Yue; Li Yuanning; Huang Ranran; Xia Yongzhen; Liu Huaiwei; Jiao Nianzhi; Xun Luying; Liu Jihua^*;Synechococcussp. PCC7002 uses Peroxiredoxin to cope with reactive sulfur species stress, mBio, 2022, 13(4).

3. Liu Daixi;Zhang Jiajie; Lü Chuanjuan; Xia Yongzhen; Liu Huaiwei; Jiao Nianzhi; Xun Luying; Liu Jihua^*;Synechococcussp. strain PCC7002 uses sulfide:quinone oxidoreductase to detoxify exogenous sulfide and to convert endogenous sulfide to cellular sulfane sulfur, mBio, 2020, 11(1).

4. Liu Daixi;Song Hui; Li Yuanning; Huang Ranran; Liu Hongyue; Tang Kunxian; Jiao Nianzhi; Liu Jihua^*; The transcriptional repressor PerR senses sulfane sulfur by Cysteine persulfidation at the structural Zn²⁺site inSynechococcussp. PCC7002, Antioxidants, 2023, 12(2) (423).

5. Liu Daixi^#;Wang Yuwei^#; Wei Lin; Ye Huahu; Liu Huan; Wang Ling; Liu Rui; Li Dongsheng; Lai Ren^*; Snake venom-like waprin from the frog ofCeratophrys calcaratacontains antimicrobial function, Gene, 2012, 514(2): 99-104.

6. Huang Ranran; Wang Yafei;Liu Daixi; Wang Shaoyu; Lv Haibo; Yanzhen^*; Long-read metagenomics of marine microbes reveals diversely expressed secondary metabolites, Microbiology Spectrum. 2023 Aug 17;11(4): e0150123.

7. Jinyu Chen;Daixi Liu; Yafei Wang; Shaoyu Wang; Ranran Huang; Effects of selective RNA processing and stabilization enzymes on carbon sequestration by photosynthesis ofSynechococcussp. PCC7002, Frontiers in Marine Science, 2023, 10(1223060)

8. Lü Chuanjuan; Xia Yongzhen;Liu Daixi;Zhao Rui; Gao Rui; Liu Honglei^*; Xun Luying^*;Cupriavidus necatorH16 uses favocytochrome c sulfide dehydrogenase to oxidize self-produced and added sulfide, Applied and Environmental Microbiology, 2017, 83(22): e01610-17.

 

五、承担课题

1.山东省自然科学基金青年项目，ZR2022QC044，2023.01-2025.12，15万，主持

2.中国博士后科学基金面上项目，2021M691913，2021.07-2023.07，8万，主持

3.国家重点研发计划，2020YFA0607604，2020.10-2025.10，39万，子子课题主持

4.青岛市应用项目资助，5万，主持